LivWell is a global longitudinal database which provides a range of key indicators related to women’s socioeconomic status, health and well-being, access to basic services, and demographic outcomes. Data are available at the sub-national level for 52 countries and 447 regions. A total of 134 indicators are based on 199 Demographic and Health Surveys for the period 1990-2019, supplemented by extensive information on socioeconomic and climatic conditions in the respective regions for a total of 190 indicators. The resulting data offer various opportunities for policy-relevant research on gender inequality, inclusive development, and demographic trends at the sub-national level.